Cis-Trans Virucidal Systems
Mag. Art. Lange-Flaig IrénPhone: +49-176-3476386-3
There are basically two antiviral approaches: Immunization; and pharmaceutical-biochemical inhibition of viral functions. Both are costly in terms of time and money, hence insufficient for emergent and/or mutation-prone viruses: Evolution can outrun the development of therapeutics. The pharmaceutical-biochemical approach also suffers from the low number of molecular targets in viruses, while the immunological approach is encumbered by the practical problems of quickly supplying billions of people with side-effect-free vaccines.
Our curative approach is based on linking a molecular mechanism with a drug delivery system, opening the perspective of developing effective and tolerable therapeutics for specific treatment of viral infections – sufficiently quickly and cheaply for combating even emergent, engineered and/or rapidly mutating viruses. The idea is to use essential functions of the virus quasi-parasitically in order to trigger antiviral processes only in virus-infected cells.
Each virus necessarily comprises a replication and packaging system for its nucleic acid, as well as nucleic acid hallmarked by certain signal sequences for its particular replication and packaging system, ensuring that only the viral and not the more abundant cellular nucleic acid is replicated and packaged. Hence, our concept is centered on combining a therapeutic nucleic acid with a specific “hallmark” sequence (cf. Spiegelman's Monster and Eigen's sequel) and introducing it by means of a drug delivery system into the host cells, where five antiviral effects can be used: Competition; antisense activity; overriding of viral effects; hijacking of nascent virions; and tagging of viral elements to uncloak the virus. Such exploitation of the “hallmark” system gives rise to a wide range of further applications, from activity-based screening kits to disease-resistant GM crops; most intriguing, however, is use of a coronaviral hallmark sequence linked to an anti-virion-maturation and/or anti-immune-escape siRNA in a liposome formulation for treatment of coronaviral airway diseases.
List of Patent Applications:
DE 10 2021 001 841.9: Sensorische Nukleinsäuren zur Diagnose und Behandlung von viralen und neoplastischen Erkrankungen
DE 10 2021 002 567.9: Weitere sensorische Nukleinsäuren zur Diagnose und Behandlung von viralen und neoplastischen Erkrankungen
DE 10 2021 003 360.4: Spezielle sensorische Nukleinsäuren zur Diagnose, Prophylaxe und Behandlung von viralen Erkrankungen
DE 10 2021 005 748.1: Replikasekettenreaktion (RCR) und ihre Verwendung in der Diagnose und Behandlung von viralen Erkrankungen